Article
Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990
Eissenberg J C, James T C, Foster-Hartnett D M, Hartnett T, Ngan V, Elgin S C
Abstract excerpt
We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role...
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