Article
Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice.
IARC scientific publications - 1 Jan 1993
Cochrane J E, Skopek T R
Abstract excerpt
The mutagenic potential of 1,3-butadiene and its epoxide metabolites have been measured in a human lymphoblastoid cell line (TK6) and in splenic T cells from exposed B6C3F1 mice. TK6 cells were exposed for 24 h to 0-400 microM 1,2-epoxybutene, 0-800 microM 3,4-epoxy-1,2-butanediol or 0-6 microM diepoxybutane and plated to measure the frequencies of mutations at the hprt and tk loci. All three metabolites were...
Topics
- Animals
- Butadienes
- Cells, Cultured
- Epoxy Compounds
- Male
- Mice
- Mice, Inbred Strains
- Mutagens
- Mutation
- T-Lymphocytes