Article
Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics.
Scientific reports - 13 Sept 2017
Raijmakers Ruud P H, Sprenkeler Evelien G G, Aleva Floor E, Jacobs Cor W M, Kanneganti Thirumala-Devi, Joosten Leo A B, van de Veerdonk Frank L, Gresnigt Mark S
Abstract excerpt
Patients with cystic fibrosis, chronic obstructive pulmonary disease, severe asthma, pre-existing pulmonary lesions, and severely immunocompromised patients are susceptible to develop infections with the opportunistic pathogenic fungus Aspergillus fumigatus, called aspergillosis. Infections in these patients are associated with persistent pro-inflammatory T-helper (TH)2 and TH17 responses. Regulatory T-cells,...
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