Article
CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.
Human immunology - 1 Jul 2010
Chan Kelvin Yuen Kwong, Xu Mei-Shu, Ching Johannes Chi Yun, So Thomas Man Kit, Lai Sik-To, Chu Chung-Ming, Yam Loretta Y C, Wong Andrew T Y, Chung Pui Hong, Chan Vera Sau Fong, Lin Chen Lung Steve, Sham Pak Chung, Leung Gabriel M, Peiris Joseph S M, Khoo Ui-Soon
Abstract excerpt
CD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory...
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