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Article

Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene.

Acta crystallographica. Section D, Biological crystallography - 1 Feb 2011

Horikoshi Naoki, Tachiwana Hiroaki, Saito Kengo, Osakabe Akihisa, Sato Mamoru, Yamada Michiyuki, Akashi Satoko, Nishimura Yoshifumi, Kagawa Wataru, Kurumizaka Hitoshi

Abstract excerpt

PAD4 is a peptidylarginine deiminase that catalyzes citrullination, a type of post-translational modification. In this reaction, arginine residues in proteins are converted to citrulline. PAD4 promotes the deimination of arginine residues in histones and may regulate transcription in the context of the chromatin. Single-nucleotide polymorphisms (SNP) in the gene encoding PAD4 identified it as one of the genes...

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Identifiers

PMID: 21245532
DOI: 10.1107/S0907444910051711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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