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Discovery of a novel allelic variant of CYP2C8, CYP2C8*11, in Asian populations and its clinical effect on the rosiglitazone disposition in vivo.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2011

Yeo Chang-Woo, Lee Su-Jun, Lee Sang Seop, Bae Soo Kyung, Kim Eun-Young, Shon Ji-Hong, Rhee Byoung Doo, Shin Jae-Gook

Abstract excerpt

The objectives of this study were to identify the genetic variants of CYP2C8, analyze CYP2C8 single nucleotide polymorphisms (SNPs), and characterize their functional consequences in the CYP2C8 substrate drug rosiglitazone in humans. The direct full sequencing of CYP2C8 genomic DNA was performed in a Korean population (n = 50). A total of 17 CYP2C8 variants including a novel coding variant (E274Stop) were...

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PMID: 21245287
DOI: 10.1124/dmd.110.035899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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