Article
Frequency of CYP2C9 variant alleles, including CYP2C9*13 in a Korean population and effect on glimepiride pharmacokinetics.
Journal of clinical pharmacy and therapeutics - 1 Feb 2012
Lee H W, Lim M-s, Lee J, Jegal M-Y, Kim D-W, Lee W-K, Jang I-J, Shin J-G, Yoon Y-R
Abstract excerpt
WHAT IS KNOWN AND OBJECTIVE: Cytochrome P450 (CYP) 2C9 is a clinically important enzyme involved in the metabolism of many drugs commonly used in humans. Of several allelic variants known to affect the catalytic activity of the CYP2C9 enzyme, the frequencies of the CYP2C9*3 and CYP2C9*13 alleles in the Korean population have been reported as 1·1% and 0·6%, respectively. Our objective was to re-evaluate the...
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