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Article

The thrifty genotype in type 2 diabetes: an unfinished symphony moving to its finale?

Endocrine - 1 Oct 1998

Joffe B, Zimmet P

Abstract excerpt

The basic premise of the thrifty gene hypothesis is that certain populations may have genes that determine increased fat storage, which in times of famine represent a survival advantage, but in a modern environment result in obesity and type 2 diabetes. The concept finds support in a unique animal model (Psammomys obesus) as well as among high type 2 diabetes susceptibility populations, such as North American...

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PMID: 9867247
DOI: 10.1385/ENDO:9:2:139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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