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Article

Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis.

The Journal of rheumatology - 1 Apr 2011

Yanagimachi Masakatsu, Naruto Takuya, Miyamae Takako, Hara Takuma, Kikuchi Masako, Hara Ryoki, Imagawa Tomoyuki, Mori Masaaki, Sato Hidenori, Goto Hiroaki, Yokota Shumpei

Abstract excerpt

OBJECTIVE: Systemic-onset juvenile idiopathic arthritis (systemic JIA) and macrophage activation syndrome (MAS), the most devastating complication of systemic JIA, are characterized by abnormal levels of proinflammatory cytokines. Interferon regulatory factor 5 (IRF5) is a member of the IRF family of transcription factors, and acts as a master transcription factor in the activation of genes encoding...

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Source

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PMID: 21239750
DOI: 10.3899/jrheum.100655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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