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Article

Variants in IRF5 Increase the Risk of Primary Sjögren's Syndrome in the Mexican Population.

International journal of molecular sciences - 7 Jan 2026

Ramírez-Bello Julian, López-Briceño Isaac Alberto, Valencia-Pacheco Guillermo, Barbosa-Cobos Rosa Elda, Hernández-Molina Gabriela, Jiménez-Morales Silvia, Aranda-Uribe Iván Sammir, Montúfar-Robles Isela, Nath Swapan K

Abstract excerpt

Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by inflammation and damage to salivary and lacrimal glands. Its etiology involves both genetic and environmental factors. Among susceptibility genes, IRF5 has been highlighted in European populations, but evidence in non-European groups remains limited. This study evaluated whether IRF5 variants rs2004640G/T, rs2070197T/C, rs10954213G/A, and...

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Case-Control Studies
Gene Frequency
Haplotypes
Interferon Regulatory Factors
Mexico

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Sjogren's Syndrome

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PMID: 41596252
DOI: 10.3390/ijms27020599
PMCID: PMC12841342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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