Article
Innate immunity gene single nucleotide polymorphisms and otitis media.
International journal of pediatric otorhinolaryngology - 1 Jul 2012
Carroll Sarah R, Zald Philip B, Soler Zachary M, Milczuk Henry A, Trune Dennis R, MacArthur Carol J
Abstract excerpt
OBJECTIVE: Toll-like receptors (TLR) activate the innate immune system. Single nucleotide polymorphisms (SNPs) in TLR genes are linked to increased susceptibility to infections. TLR4-deficient mice have increased incidence and duration of otitis media. We hypothesize that SNPs in TLR genes are more common in otitis-prone children than in children without a history of otitis media. METHODS: Cases (n=70) included...
Topics
- Adolescent
- Case-Control Studies
- Child
- Child, Preschool
- Female
- Genetic Predisposition to Disease
- Humans
- Immunity, Innate
- Infant
- Lipopolysaccharide Receptors
- Male