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Article

TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media

8 Jul 2009

Abstract excerpt

Otitis media is the most prevalent childhood disease in developed countries. The involvement of Toll-like receptors (TLRs) in otitis media pathophysiology has been implicated by studies in cell lines and association studies of TLR gene polymorphisms. However, precise functions of TLRs in the etiology of otitis media in vivo have not been examined. We investigated the inflammatory response to nontypeable...

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PMID: 19586996
DOI: 10.1177/1753425909103170

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