Differences in innate immune response gene regulation in the middle ear of children who are otitis prone and in those not otitis prone.

doi:10.2500/ajra.2016.30.4393

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Article

Differences in innate immune response gene regulation in the middle ear of children who are otitis prone and in those not otitis prone.

American journal of rhinology & allergy - 1 Nov 2016

Kaur Ravinder, Casey Janet, Pichichero Michael

Abstract excerpt

OBJECTIVE: Acute otitis media (AOM) causes an inflammatory response in the middle ear. We assessed differences in innate immune responses involved in bacterial defense at onset of AOM in children who were stringently defined as otitis prone (sOP) and children not otitis prone (NOP). STUDY DESIGN: Innate immune genes analysis from middle ear fluid (MEF) samples of children. METHODS: Genes of toll-like receptors...

Topics

Adolescent
Chemokine CCL3
Chemokine CCL5
Child
Ear, Middle
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Haemophilus parainfluenzae
Humans
Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon Regulatory Factor-7

Interferon-alpha

Interleukin-8

Male

Otitis Media

Prospective Studies

Secretory Leukocyte Peptidase Inhibitor

Source

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Identifiers

PMID: 28124644
DOI: 10.2500/ajra.2016.30.4393
PMCID: PMC5108842

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