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Article

Screening for large genomic rearrangements in the FANCA gene reveals extensive deletion in a Finnish breast cancer family.

Cancer letters - 28 Mar 2011

Solyom Szilvia, Winqvist Robert, Nikkilä Jenni, Rapakko Katrin, Hirvikoski Pasi, Kokkonen Hannaleena, Pylkäs Katri

Abstract excerpt

A portion of familial breast cancer cases are caused by mutations in the same genes that are inactivated in the downstream part of Fanconi anemia (FA) signaling pathway. Here we have assessed the FANCA gene for breast cancer susceptibility by examining blood DNA for aberrations from 100 Northern Finnish breast cancer families using the MLPA method. We identified a novel heterozygous deletion, removing the...

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Source

Identifiers

PMID: 21236561
DOI: 10.1016/j.canlet.2010.12.020

Genes

FANCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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