Article
Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer.
Clinical genetics - 1 Jul 2015
Mantere T, Haanpää M, Hanenberg H, Schleutker J, Kallioniemi A, Kähkönen M, Parto K, Avela K, Aittomäki K, von Koskull H, Hartikainen J M, Kosma V-M, Laasanen S-L, Mannermaa A, Pylkäs K, Winqvist R
Abstract excerpt
Mutations in downstream Fanconi anemia (FA) pathway genes, BRCA2, PALB2, BRIP1 and RAD51C, explain part of the hereditary breast cancer susceptibility, but the contribution of other FA genes has remained questionable. Due to FA's rarity, the finding of recurrent deleterious FA mutations among breast cancer families is challenging. The use of founder populations, such as the Finns, could provide some advantage in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.