Article
A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer.
BMC cancer - 29 Apr 2005
Thompson Ella, Dragovic Rebecca L, Stephenson Sally-Anne, Eccles Diana M, Campbell Ian G, Dobrovic Alexander
Abstract excerpt
UNLABELLED: The FANCA gene is one of the genes in which mutations lead to Fanconi anaemia, a rare autosomal recessive disorder characterised by congenital abnormalities, bone marrow failure, and predisposition to malignancy. FANCA is also a potential breast and ovarian cancer susceptibility gene. A novel allele was identified which has a tandem duplication of a 13 base pair sequence in the promoter region....
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