Large genomic BRCA2 rearrangements and male breast cancer.

Abstract excerpt

BACKGROUND: Germ-line mutations of the BRCA2 gene are the highest known risk factors for male breast cancer (MBC). Mutations in BRCA2 are mainly point mutations in contrast to BRCA1 in which large genomic rearrangements are quite common. In recent literature, however, genomic alterations of BRCA2 have been linked especially to male breast cancer families. We wanted to screen large genomic deletions and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Breast Neoplasms, Male
• Share to Chromosomes, Human, Pair 13
• Share to DNA Probes