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Article

Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.

Free radical biology & medicine - 1 Jan 2010

Marchette Lea D, Thompson Debra A, Kravtsova Marina, Ngansop Thierry N, Mandal Md Nawajes A, Kasus-Jacobi Anne

Abstract excerpt

Mutations of the photoreceptor retinol dehydrogenase 12 (RDH12) gene cause the early onset retinal dystrophy Leber congenital amaurosis (LCA) by mechanisms not completely resolved. Determining the physiological role of RDH12 in photoreceptors is the focus of this study. Previous studies showed th...

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Source

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Identifiers

PMID: 19686838
DOI: 10.1016/j.freeradbiomed.2009.08.005
PMCID: PMC2874966

Genes

RDH12
RDH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19686838-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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