Article
The emergent dynamics of isotype switch.
Autoimmunity - 1 Jun 2011
Stewart Jeffrey J, Vahadji Cordelia, Seiden Philip E
Abstract excerpt
The supplanting of the 1° IgM response by the 2° isotype-switched response is one of the best known phenomena of immune system dynamics. Given that the conditions determining which B cells will switch isotype and which ones will not are intrinsic to the entities of the immune system, it should be possible to predict the effects that the small-scale (e.g. molecular) properties have on the large scale dynamics of...
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