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Article

BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms.

International journal of cancer - 20 Jul 2005

Ikehara Nobunao, Semba Shuho, Sakashita Masanori, Aoyama Nobuo, Kasuga Masato, Yokozaki Hiroshi

Abstract excerpt

To understand the role of BRAF dysfunction in the carcinogenesis and progression/development of colorectal tumors, the authors investigated genetic alterations in the BRAF gene in human colorectal neoplasms as well as the effects of an RAS inhibitor in BRAF-mutant cells. Seven colon cancer cell lines and 116 colorectal tumors (34 adenomas and 82 adenocarcinomas) were analyzed. Genetic alterations in the BRAF and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15729718
DOI: 10.1002/ijc.20957

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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