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Article

Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2013

Garcia-Carracedo Dario, Turk Andrew T, Fine Stuart A, Akhavan Nathan, Tweel Benjamin C, Parsons Ramon, Chabot John A, Allendorf John D, Genkinger Jeanine M, Remotti Helen E, Su Gloria H

Abstract excerpt

PURPOSE: Previously, we reported PIK3CA gene mutations in high-grade intraductal papillary mucinous neoplasms (IPMN). However, the contribution of phosphatidylinositol-3 kinase pathway (PI3K) dysregulation to pancreatic carcinogenesis is not fully understood and its prognostic value unknown. We investigated the dysregulation of the PI3K signaling pathway in IPMN and its clinical implication. EXPERIMENTAL DESIGN:...

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Topics

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Gene Expression Regulation, Neoplastic

Share to Immunohistochemistry

Share to Pancreatic Neoplasms

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Share to PTEN Phosphohydrolase

Source

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Identifiers

PMID: 24132918
DOI: 10.1158/1078-0432.CCR-13-0624
PMCID: PMC3915026

Genes

PTEN
AKT1
PDK1
PDPK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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