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Article

Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas.

Pancreas - 1 Mar 2008

Schönleben Frank, Allendorf John D, Qiu Wanglong, Li Xiaojun, Ho Daniel J, Ciau Nancy T, Fine Robert L, Chabot John A, Remotti Helen E, Su Gloria H

Abstract excerpt

OBJECTIVE: There is much accumulated evidence that EGFR, HER2, and their downstream signaling pathway members such as KRAS, BRAF, and PIK3CA are strongly implicated in cancer development and progression. Recently, mutations in the kinase domains of EGFR and HER2, associated with increased sensitivity to tyrosine kinase inhibitors, have been described. METHODS: To evaluate the mutational status of these genes in...

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Topics

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Share to Adenocarcinoma, Mucinous
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18376308
DOI: 10.1097/MPA.0b013e318158a4d2
PMCID: PMC3915029

Genes

EGFR
BRAF
KRAS
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas.PMID 18376308Read ↗

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