Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment.

doi:10.1007/s13365-010-0014-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment.

Journal of neurovirology - 1 Feb 2011

Li Luna, Aiamkitsumrit Benjamas, Pirrone Vanessa, Nonnemacher Michael R, Wojno Adam, Passic Shendra, Flaig Katherine, Kilareski Evelyn, Blakey Brandon, Ku Jade, Parikh Nirzari, Shah Rushabh, Martin-Garcia Julio, Moldover Brian, Servance Laila, Downie David, Lewis Sharon, Jacobson Jeffrey M, Kolson Dennis, Wigdahl Brian

Abstract excerpt

The long terminal repeat (LTR) regulates gene expression of HIV-1 by interacting with multiple host and viral factors. Cross-sectional studies in the pre-HAART era demonstrated that single nucleotide polymorphisms (SNPs) in peripheral blood-derived LTRs (a C-to-T change at position 3 of C/EBP site I (3T) and at position 5 of Sp site III (5T)) increased in frequency as disease severity increased. Additionally, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Dementia Complex

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to Gene Expression Regulation, Viral

Share to HIV Long Terminal Repeat

Share to Longitudinal Studies

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Transcriptional Activation

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 21225391
DOI: 10.1007/s13365-010-0014-1
PMCID: PMC3057211

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment.PMID 21225391Read ↗

Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes.Semantic proximity Read ↗

Genetic variation and HIV-associated neurologic disease.Semantic proximity Read ↗

The Genetic Fingerprint of HIV in the Brain: Insights into Neurocognitive DysfunctionSemantic proximity Read ↗

Impact of viral activators and epigenetic regulators on HIV-1 LTRs containing naturally occurring single nucleotide polymorphisms.Semantic proximity Read ↗

The evolution of regulatory elements in the emerging promoter variant strains of HIV-1Semantic proximity Read ↗

HIV-1 Genetic Variation Resulting in the Development of New Quasispecies Continues to Be Encountered in the Peripheral Blood of Well-Suppressed Patients.Semantic proximity Read ↗

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.Semantic proximity Read ↗

The Evolution of Regulatory Elements in the Emerging Promoter-Variant Strains of HIV-1 Subtype CSemantic proximity Read ↗

Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia.Semantic proximity Read ↗

Reduced basal transcriptional activity of central nervous system-derived HIV type 1 long terminal repeats.Semantic proximity Read ↗

Human immunodeficiency virus type 1 genetic diversity in the nervous system: evolutionary epiphenomenon or disease determinant?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.