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Article

Reduced basal transcriptional activity of central nervous system-derived HIV type 1 long terminal repeats.

AIDS research and human retroviruses - 1 Feb 2013

Gray Lachlan R, Cowley Daniel, Crespan Emma, Welsh Casey, Mackenzie Charlene, Wesselingh Steve L, Gorry Paul R, Churchill Melissa J

Abstract excerpt

New evidence indicates that astrocytes of the central nervous system (CNS) are extensively infected with human immunodeficiency virus type 1 (HIV-1) in vivo. Although no new virus is produced, this nonproductive or restricted infection contributes to the pathogenesis of HIV-associated dementia (HAD) and compromises virus eradication strategies. The HIV-1 long terminal repeat (LTR) plays a critical role in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22924643
DOI: 10.1089/AID.2012.0138
PMCID: PMC3552182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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