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Article

Mutational Heterogeneity in Melanoma: An Inconvenient Truth.

The Journal of investigative dermatology - 1 Dec 2015

Chang Gregory A, Polsky David

Abstract excerpt

Identification of oncogenic BRAF mutations in primary and metastatic melanomas supports a linear model of clonal evolution in cancer. Some mutational studies, however, have failed to identify BRAF mutations in metastatic tumors from patients with BRAFmutant primary melanomas. Using a combination of methods, Riveiro-Falkenbach et al. (2015) assert that technical issues, and not clonal heterogeneity, may explain...

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Identifiers

PMID: 26569584
DOI: 10.1038/jid.2015.351

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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