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Article

Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2009

Henrion Ulrike, Strutz-Seebohm Nathalie, Duszenko Michael, Lang Florian, Seebohm Guiscard

Abstract excerpt

The plateau phase of the ventricular action potential is the result of balanced Ca2+ influx and K+ efflux. The action potential is finally terminated by repolarising K+ currents. Under beta-adrenergic stimulation the slowly activating component of the human cardiac delayed rectifier K+ current I(Ks) provides the major repolarising component. I(Ks) channels are heteromeric channels composed of KCNQ1 and KCNE1....

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Source

Identifiers

PMID: 19590188
DOI: 10.1159/000227828

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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