Article
123I-MIBG cardiac uptake and smell identification in parkinsonian patients with LRRK2 mutations.
Journal of neurology - 1 Jun 2011
Valldeoriola Francesc, Gaig Carles, Muxí Africa, Navales Ignacio, Paredes Pilar, Lomeña Francisco, De la Cerda Andres, Buongiorno Mariateresa, Ezquerra Mario, Santacruz Pilar, Martí Maria Jose, Tolosa Eduardo
Abstract excerpt
Reduced uptake of (123)I- metaiodobenzylguanidine (MIBG) on cardiac gammagraphy and impaired odor identification are markers of neurodegenerative diseases with Lewy bodies (LB) as a pathological hallmark, such as idiopathic Parkinson's disease (IPD). LRRK2 patients present with a clinical syndrome indistinguishable from IPD, but LB have not been found in some cases. Patients with such mutations could behave...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.