Article
Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data.
Neurology - 23 Sept 2008
Silveira-Moriyama L, Guedes L C, Kingsbury A, Ayling H, Shaw K, Barbosa E R, Bonifati V, Quinn N P, Abou-Sleiman P, Wood N W, Petrie A, Sampaio C, Ferreira J J, Holton J, Revesz T, Lees A J
Abstract excerpt
BACKGROUND: Mutations in PARK8 (LRRK2) are associated with autosomal dominant parkinsonism and Parkinson disease (PD). Hyposmia is present in at least 80% of patients with PD and an accumulation of alpha-synuclein (alpha-syn) is seen in the olfactory pathways. In this study we have clinically examined olfaction and pathologically examined the rhinencephalon in individuals carrying the G2019S LRRK2 mutation....
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