Article
Myocardial 123I-metaiodobenzylguanidine scintigraphy in patients with homozygous and heterozygous parkin mutations.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology - 1 Feb 2017
De Rosa Anna, Pellegrino Teresa, Pappatà Sabina, Pellecchia Maria Teresa, Peluso Silvio, Saccà Francesco, Barone Paolo, Cuocolo Alberto, De Michele Giuseppe
Abstract excerpt
BACKGROUND: PARK2 is an autosomal recessive parkinsonism caused by parkin gene mutations. Several Parkinson's Disease (PD) cases harbor single parkin mutations, raising a debate about the pathogenic meaning of heterozygous mutations. Here, we evaluate cardiac autonomic innervation in patients with either two or one parkin mutations compared to patients with idiopathic PD (IPD). PATIENTS AND METHODS: Myocardial...
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