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Article

KZ02 enhances the radiosensitivity of BRAF-mutated CRC in vitro and in vivo.

European journal of pharmacology - 15 Nov 2023

Guo Yuying, Li Xuejiao, Yuan Renbin, Ren Jingming, Huang Yichi, Yu Yanxiang, Tian Hongqi

Abstract excerpt

Colorectal cancer (CRC) is a common malignant tumor with a high incidence and mortality worldwide. Preoperative chemoradiotherapy is a common treatment for patients with metastatic colorectal cancer (mCRC) as it reduces colostomy and local recurrence. The RAS (rat sarcoma)-RAF (extracellular signal-regulated kinase)-MEK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) pathway...

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Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins c-bcl-2

Radiation Tolerance

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Identifiers

PMID: 37775019
DOI: 10.1016/j.ejphar.2023.176060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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