Article
p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells.
Molecular cancer - 13 Dec 2005
Ciccarelli Carmela, Marampon Francesco, Scoglio Arianna, Mauro Annunziata, Giacinti Cristina, De Cesaris Paola, Zani Bianca M
Abstract excerpt
BACKGROUND: p21WAF1, implicated in the cell cycle control of both normal and malignant cells, can be induced by p53-dependent and independent mechanisms. In some cells, MEKs/ERKs regulate p21WAF1 transcriptionally, while in others they also affect the post-transcriptional processes. In myogenic differentiation, p21WAF1 expression is also controlled by the myogenic transcription factor MyoD. We have previously...
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