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Article

Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.

Clinical immunology (Orlando, Fla.) - 1 Jul 2001

Lewis J, Eiben L J, Nelson D L, Cohen J I, Nichols K E, Ochs H D, Notarangelo L D, Duckett C S

Abstract excerpt

X-linked lymphoproliferative syndrome (XLP; Duncan's disease) is a primary immunodeficiency disease that manifests as an inability to regulate the immune response to Epstein-Barr virus (EBV) infection. Here we examine the ability of the product of the gene defective in XLP, SAP (DSHP/SH2D1A), to associate with the cytoplasmic domains of several members of the CD2 subfamily of cell surface receptors, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Identifiers

PMID: 11414741
DOI: 10.1006/clim.2001.5035

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Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.PMID 11414741Read ↗

Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAPSemantic proximity Read ↗

SLAM family receptors and SAP adaptors in immunity.Semantic proximity Read ↗

The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease.Semantic proximity Read ↗

Pathogenesis and diagnosis of X-linked lymphoproliferative disease.Semantic proximity Read ↗

XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.Semantic proximity Read ↗

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.Semantic proximity Read ↗

X-linked lymphoproliferative disease: a progressive immunodeficiency.Semantic proximity Read ↗

Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.Semantic proximity Read ↗

Regulation of Cellular and Humoral Immune Responses by the SLAM and SAP Families of MoleculesSemantic proximity Read ↗

Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462-469.Semantic proximity Read ↗

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.Semantic proximity Read ↗

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.Semantic proximity Read ↗

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