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Article

Integration of genetic and immunological insights into a model of celiac disease pathogenesis.

Annual review of immunology - 1 Jan 2011

Abadie Valérie, Sollid Ludvig M, Barreiro Luis B, Jabri Bana

Abstract excerpt

Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically susceptible individuals by exposure to cereal gluten proteins. This review integrates insights from immunological studies with results of recent genetic genome-wide association studies into a disease model. Genetic data, among others, suggest that viral infections are implicated and that natural killer effector pathways are...

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PMID: 21219178
DOI: 10.1146/annurev-immunol-040210-092915

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