Article
Impaired autophagy in macrophages promotes inflammatory eye disease.
Autophagy - 2 Oct 2016
Santeford Andrea, Wiley Luke A, Park Sunmin, Bamba Sonya, Nakamura Rei, Gdoura Abdelaziz, Ferguson Thomas A, Rao P Kumar, Guan Jun-Lin, Saitoh Tatsuya, Akira Shizuo, Xavier Ramnik, Virgin Herbert W, Apte Rajendra S
Abstract excerpt
Autophagy is critical for maintaining cellular homeostasis. Organs such as the eye and brain are immunologically privileged. Here, we demonstrate that autophagy is essential for maintaining ocular immune privilege. Deletion of multiple autophagy genes in macrophages leads to an inflammation-mediated eye disease called uveitis that can cause blindness. Loss of autophagy activates inflammasome-mediated IL1B...
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