Article
Identification of FAT3 as a new candidate gene for adolescent idiopathic scoliosis.
Scientific reports - 19 Jul 2022
Nada Dina, Julien Cédric, Papillon-Cavanagh Simon, Majewski Jacek, Elbakry Mohamed, Elremaly Wesam, Samuels Mark E, Moreau Alain
Abstract excerpt
In an effort to identify rare alleles associated with adolescent idiopathic scoliosis (AIS) whole-exome sequencing was performed on a discovery cohort of 73 unrelated patients and 70 age-and sex matched controls, all of French-Canadian ancestry. A collapsing gene burden test was performed to analyze rare protein-altering variants using case-control statistics. Since no single gene achieved statistical...
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