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Article

Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q.

Biological & pharmaceutical bulletin - 1 Jan 2011

Goto Yoshikuni, Yoshioka Rina, Arisaka Naomi, Hattori Akira, Tsujimoto Masafumi

Abstract excerpt

Human laeverin/aminopeptidase Q (APQ) is a novel member of the M1 family of zinc aminopeptidases and is specifically expressed on the cell surface of extravillous trophoblasts. In this study, we examined the significance of Gln-238 of laeverin/APQ, a putative S1 site residue, by site-directed mutagenesis for its enzymatic activity and substrate specificity. Replacement of Gln-238 with Ala caused a significant...

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Identifiers

PMID: 21212512
DOI: 10.1248/bpb.34.24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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