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Article

Function assignment to conserved residues in mammalian alkaline phosphatases.

The Journal of biological chemistry - 21 Jun 2002

Kozlenkov Alexey, Manes Thomas, Hoylaerts Marc F, Millán José Luis

Abstract excerpt

We have probed the structural/functional relationship of key residues in human placental alkaline phosphatase (PLAP) and compared their properties with those of the corresponding residues in Escherichia coli alkaline phosphatase (ECAP). Mutations were introduced in wild-type PLAP, i.e. [E429]PLAP, and in some instances also in [G429]PLAP, which displays properties characteristic of the human germ cell alkaline...

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PMID: 11937510
DOI: 10.1074/jbc.M202298200

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