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Article

Identification of glutamic acid 646 as a zinc-coordinating residue in endopeptidase-24.11.

The Journal of biological chemistry - 25 Aug 1991

Le Moual H, Devault A, Roques B P, Crine P, Boileau G

Abstract excerpt

Neutral endopeptidase (EC 3.424.11, NEP) is a membrane-bound zinc-metallopeptidase. The substrate specificity and catalytic activity of NEP resemble those of thermolysin, a bacterial zinc-metalloprotease. Comparison of the primary structure of both enzymes suggests that several amino acids present in the active site of thermolysin are also found in NEP. Using site-directed mutagenesis of the cDNA encoding the NEP...

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PMID: 1678740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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