Article
Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P.
Biochemistry - 12 Dec 2000
Cottrell G S, Hyde R J, Lim J, Parsons M R, Hooper N M, Turner A J
Abstract excerpt
The membrane-bound form of mammalian aminopeptidase P (AP-P; EC 3.4. 11.9) is a mono-zinc-containing enzyme that lacks any of the typical metal binding motifs found in other zinc metalloproteases. To identify residues involved in metal binding and catalysis, sequence and structural information was used to align the sequence of porcine membrane-bound AP-P with other members of the peptidase clan MG, including...
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