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Article

Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family.

The Journal of biological chemistry - 7 Jul 2006

Chávez-Gutiérrez Lucía, Matta-Camacho Edna, Osuna Joel, Horjales Eduardo, Joseph-Bravo Patricia, Maigret Bernard, Charli Jean-Louis

Abstract excerpt

Pyroglutamyl peptidase II (PPII), a highly specific membrane-bound omegapeptidase, removes N-terminal pyroglutamyl from thyrotropin-releasing hormone (<Glu-His-Pro-NH(2)), inactivating the peptide in the extracellular space. PPII and enzymes with distinct specificities such as neutral aminopeptidase (APN), belong to the M1 metallopeptidase family. M1 aminopeptidases recognize the N-terminal amino group of...

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Identifiers

PMID: 16611635
DOI: 10.1074/jbc.M601392200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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