Article
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Aging - 1 Dec 2010
Hafner Angela V, Dai Jing, Gomes Ana P, Xiao Chun-Yang, Palmeira Carlos M, Rosenzweig Anthony, Sinclair David A
Abstract excerpt
Cardiac failure is a leading cause of age-related death, though its root cause remains unknown. Mounting evidence implicates a decline in mitochondrial function due to increased opening of the mitochondrial permeability transition pore (mPTP). Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding site...
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