Article
Nicotine Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2017
Wang Chen, Chen Han, Zhu Wei, Xu Yinchuan, Liu Mingfei, Zhu Lianlian, Yang Fan, Zhang Ling, Liu Xianbao, Zhong Zhiwei, Zhao Jing, Jiang Jun, Xiang Meixiang, Yu Hong, Hu Xinyang, Lu Hong, Wang Jian'an
Abstract excerpt
OBJECTIVE: Cigarette smoking is an independent risk factor for atherosclerosis. Nicotine, the addictive component of cigarettes, induces mast cell (MC) release and contributes to atherogenesis. The purpose of this study was to determine whether nicotine accelerates atherosclerosis through MC-mediated mechanisms and whether MC stabilizer prevents this pathological process. APPROACH AND RESULTS: Nicotine...
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