Article
Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families.
Circulation research - 4 Feb 2011
Arnett Donna K, Meyers Kristin J, Devereux Richard B, Tiwari Hemant K, Gu Charles C, Vaughan Laura K, Perry Rodney T, Patki Amit, Claas Steven A, Sun Yan V, Broeckel Ulrich, Kardia Sharon L
Abstract excerpt
RATIONALE: Left ventricular (LV) mass and related phenotypes are heritable, important predictors of cardiovascular disease, particularly in hypertensive individuals. OBJECTIVE: Identify genetic predictors of echocardiographic phenotypes in hypertensive families. METHODS AND RESULTS: A multistage genome-wide association study (GWAS) was conducted in hypertensive-ascertained black families (HyperGEN, stage I;...
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