Article
Breast cancer risk models: a comprehensive overview of existing models, validation, and clinical applications.
Breast cancer research and treatment - 1 Jul 2017
Cintolo-Gonzalez Jessica A, Braun Danielle, Blackford Amanda L, Mazzola Emanuele, Acar Ahmet, Plichta Jennifer K, Griffin Molly, Hughes Kevin S
Abstract excerpt
Numerous models have been developed to quantify the combined effect of various risk factors to predict either risk of developing breast cancer, risk of carrying a high-risk germline genetic mutation, specifically in the BRCA1 and BRCA2 genes, or the risk of both. These breast cancer risk models can be separated into those that utilize mainly hormonal and environmental factors and those that focus more on...
Topics
- Breast Neoplasms
- Confounding Factors, Epidemiologic
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Models, Statistical
- Risk Assessment
- Risk Factors