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Article

A crystal structure of the catalytic core domain of an avian sarcoma and leukemia virus integrase suggests an alternate dimeric assembly.

PloS one - 1 Jan 2011

Ballandras Allison, Moreau Karen, Robert Xavier, Confort Marie-Pierre, Merceron Romain, Haser Richard, Ronfort Corinne, Gouet Patrice

Abstract excerpt

Integrase (IN) is an important therapeutic target in the search for anti-Human Immunodeficiency Virus (HIV) inhibitors. This enzyme is composed of three domains and is hard to crystallize in its full form. First structural results on IN were obtained on the catalytic core domain (CCD) of the avian Rous and Sarcoma Virus strain Schmidt-Ruppin A (RSV-A) and on the CCD of HIV-1 IN. A ribonuclease-H like motif was...

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Identifiers

PMID: 21857987
DOI: 10.1371/journal.pone.0023032
PMCID: PMC3153463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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