Article
Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability.
PloS one - 31 Dec 2010
Williams David S, Bird Matthew J, Jorissen Robert N, Yu Yen Lin, Walker Francesca, Walker Franscesa, Zhang Hui Hua, Nice Edouard C, Burgess Antony W
Abstract excerpt
BACKGROUND: Frameshift mutations in microsatellite instability high (MSI-High) colorectal cancers are a potential source of targetable neo-antigens. Many nonsense transcripts are subject to rapid degradation due to nonsense-mediated decay (NMD), but nonsense transcripts with a cMS in the last exon or near the last exon-exon junction have intrinsic resistance to nonsense-mediated decay (NMD). NMD-resistant...
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