Article

Widespread immunogenic poly-epitope frameshift mutations in microsatellite unstable tumors

2019-06-06

Abstract excerpt

Microsatellite instability-high (MSI-H) tumors are an important model system for evaluating neoantigen-based immunotherapies given their high tumor mutation burden and response to checkpoint blockade. We identified tumor-specific, frameshift peptides, encoding multiple epitopes that originated from indel mutations shared among patients with MSI-H endometrial, colorectal and stomach cancers. Epitopes derived from t...

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Literature Corpus work: 2e660982-af8f-5617-a517-190ac80a7ea1
DOI: 10.1101/662262

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