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Article

Opportunities for immunotherapy in microsatellite instable colorectal cancer.

Cancer immunology, immunotherapy : CII - 1 Oct 2016

Westdorp Harm, Fennemann Felix L, Weren Robbert D A, Bisseling Tanya M, Ligtenberg Marjolijn J L, Figdor Carl G, Schreibelt Gerty, Hoogerbrugge Nicoline, Wimmers Florian, de Vries I Jolanda M

Abstract excerpt

Microsatellite instability (MSI), the somatic accumulation of length variations in repetitive DNA sequences called microsatellites, is frequently observed in both hereditary and sporadic colorectal cancer (CRC). It has been established that defects in the DNA mismatch repair (MMR) pathway underlie the development of MSI in CRC. After the inactivation of the DNA MMR pathway, misincorporations, insertions and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27060000
DOI: 10.1007/s00262-016-1832-7
PMCID: PMC5035655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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