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Article

RNAi screen of DAF-16/FOXO target genes in C. elegans links pathogenesis and dauer formation.

PloS one - 31 Dec 2010

Jensen Victor L, Simonsen Karina T, Lee Yu-Hui, Park Donha, Riddle Donald L

Abstract excerpt

The DAF-16/FOXO transcription factor is the major downstream output of the insulin/IGF1R signaling pathway controlling C. elegans dauer larva development and aging. To identify novel downstream genes affecting dauer formation, we used RNAi to screen candidate genes previously identified to be regulated by DAF-16. We used a sensitized genetic background [eri-1(mg366); sdf-9(m708)], which enhances both RNAi...

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Identifiers

PMID: 21209831
DOI: 10.1371/journal.pone.0015902
PMCID: PMC3013133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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