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Article

The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise

5 Jan 2011

Abstract excerpt

A large fraction of human tumors carry p53 mutations, which allow tumor initiation and progression; furthermore, it is now clear that restoration or reactivation of wild-type p53 function prompts rapid elimination of tumors. The discovery and design of compounds that reactivate or enhance the p53 pathway has resulted in the identification of promising drug candidates that have now entered clinical trials for...

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PMID: 21209413
DOI: 10.1126/scitranslmed.3001366

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